Discussion
Which amino acid has an imidazole ring?
Answer: B
The amino acid with an imidazole ring is histidine.
Histidine's side chain is an imidazole ring, a five-membered ring with two nitrogen atoms. Its pKa of about 6 lets it gain or lose a proton near body pH, which makes histidine an important buffer, as in haemoglobin, and a common catalytic residue in enzymes.
Serine has a simple hydroxyl (-CH2OH) side chain. Tyrosine carries a phenol ring, which has no nitrogen. Arginine has a guanidino group, which contains nitrogen but is not a ring.
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