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The most reliable way to establish a safe batch process at plant scale is to

  • A.assume the laboratory result scales directly
  • B.run the plant batch a good deal quicker
  • C.raise the reaction temperature further
  • D.compare heat release with cooling capacity

Answer: D

Reaction calorimetry gives the heat output against time and can be compared with what the jacket can actually remove. This comparison is what a proper scale-up assessment rests on. Peak heat release is the number that matters.

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