Discussion
Consider the following statements about cell cycle checkpoints.
1. The G1 checkpoint assesses DNA damage and cell size.
2. The spindle checkpoint acts during mitosis.
3. Checkpoints operate only in cancer cells.
Answer: A
The first two are correct. The third inverts the truth, since checkpoints are a normal feature that cancer cells commonly lose, and it is that loss which allows damaged cells to keep dividing. Checkpoints are a safeguard that cancer characteristically dismantles.
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