Discussion
The relationship between genes and enzymes was first suggested by the discovery of
Answer: A
The link was first suggested by the discovery of in-born errors of metabolism in human.
Archibald Garrod, studying alkaptonuria in the early 1900s, saw that it was inherited as a Mendelian recessive trait and that patients failed to break down homogentisic acid. He proposed that the condition was an 'inborn error of metabolism' caused by the absence of a particular enzyme, the first suggestion that genes act through enzymes.
Beadle and Tatum's work on metabolic pathways in the fungus Neurospora (1941) gave the 'one gene, one enzyme' hypothesis its experimental proof, but it came decades later. Sex determination in insects and gene regulation in bacteria are not where the idea began.
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