Discussion
Assertion (A): In I-cell disease, lysosomal enzymes are found in the bloodstream rather than in lysosomes.
Reason (R): The enzyme that adds the mannose-6-phosphate tag is defective.
Answer: C
Both are true and the reason gives the cause directly: without the tag the enzymes are not recognised for lysosomal delivery and follow the default route out of the cell, leaving the lysosomes full of undigested material.
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