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The unfolded protein response is triggered when

  • A.misfolded proteins accumulate in the reticulum
  • B.the cell runs short of adenosine triphosphate
  • C.the nuclear envelope breaks down at mitosis
  • D.lysosomal enzymes leak into the cytosol

Answer: A

The cell slows translation, makes more chaperones and increases degradation until the backlog clears. If the stress persists too long, the same pathway can instead trigger programmed cell death. A cell that cannot restore order is safer removed than left to misfold indefinitely.

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