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State whether the following is true or false.
A protein synthesised on a free ribosome in the cytosol can still be delivered to a mitochondrion.

  • A.False
  • B.True only at large scales
  • C.False only at small scales
  • D.True

Answer: D

Correct answer: True

Mitochondrial proteins are made on free ribosomes and imported afterwards. They carry an N-terminal targeting presequence recognised by translocase complexes in the outer and inner membranes, and are threaded through unfolded, with the presequence cleaved on arrival. It is a quite separate route from the secretory pathway, which commits a protein to the reticulum during translation rather than after it.

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