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Discussion

Monooxygenases that catalyse the additions of -OH during steroid biosynthesis and drug detoxifications are present in :

  • A.Peroxisomes
  • B.Smooth endoplasmic reticulum
  • C.Golgi complex
  • D.Rough endoplasmic reticulum

Answer: B

These monooxygenases are present in the Smooth endoplasmic reticulum.

The cytochrome P450 monooxygenases, which add an -OH group using O2 and NADPH, sit in the membranes of the smooth ER (the microsomal fraction), especially in liver and in steroid-producing cells. They hydroxylate steroids during their synthesis and make drugs and toxins more water-soluble for excretion.

Peroxisomes hold oxidases and catalase rather than these hydroxylases, the Golgi complex processes and sorts proteins, and the rough ER is the site of protein synthesis on ribosomes.

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