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Nowadays blood glucose is measured by glucometer, where the glucose is measured by :

  • A.rate of disappearance of substrate
  • B.rate of appearance of product
  • C.rate of electron flow from glucose to an electrode surface
  • D.rate of electron flow from electron donor to glucose

Answer: C

A glucometer measures the rate of electron flow from glucose to an electrode surface.

Most test strips are amperometric biosensors. Glucose oxidase (or glucose dehydrogenase) on the strip oxidises glucose, taking electrons from it; a mediator such as ferricyanide carries those electrons to the electrode. The current produced is proportional to the glucose concentration in the drop of blood, and the meter converts it to a reading.

The meter does not track the disappearance of glucose or the appearance of gluconolactone as such, which would need a separate chemical measurement. Electrons flow from glucose, which is oxidised, so 'electron flow from a donor to glucose' has the direction reversed.

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