Discussion
In non-competitive inhibition, ...........
Answer: B
In non-competitive inhibition, the inhibitor binds at a site other than the active site and may bind to either E or ES complex.
Because the non-competitive inhibitor does not occupy the active site, substrate binding is not blocked, and in the pure case the inhibitor binds the free enzyme and the enzyme-substrate complex equally well. The inhibited complexes cannot make product, so \(V_{max}\) falls, while \(K_m\) is unchanged. Raising substrate concentration cannot overcome it.
Binding at the active site describes competitive inhibition. Binding only to the ES complex is uncompetitive inhibition, which lowers both \(V_{max}\) and \(K_m\). An inhibitor binding only free E away from the active site, the last option, is not the textbook definition of the non-competitive type.
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