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Serum protein polymorphism are demonstrated by

  • A.HPLC
  • B.Centrifugation
  • C.GC-MS
  • D.Electrophoresis

Answer: D

Serum protein polymorphism is demonstrated by electrophoresis. Genetic variants of proteins such as haptoglobin, transferrin and group specific component differ in charge or size, so they migrate to different positions in an electric field and give different band patterns.

HPLC and GC-MS are used for small molecules such as drugs. Centrifugation separates components by density and cannot display variants of a single protein. Only electrophoresis separates the protein variants.

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