Discussion
What is the general elution problem?
Answer: A
A mixture spanning a wide range of volatility cannot be run isothermally without either crowding the early peaks or waiting indefinitely for the late ones. The other options describe real observations that are consequences rather than the problem itself. Naming the difficulty explains why programming exists, and the same problem in liquid chromatography is solved by gradient elution for exactly the same reason. A single measurement chosen to respond to the one asymmetry beats several that respond to shared behaviour.
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