Discussion
The following list describes the specific activities and goals of associated with genome analysis. Indicate which one of the following cannot be described as an example of functional genomics.
Answer: D
The activity that is not functional genomics is sequencing BAC or PAC clones aligned in a contig by the shotgun approach.
Sequencing and assembling clones in a contig determines the genome's sequence and map, which is structural genomics.
Functional genomics asks what the genes do. Knocking out genes and observing the resulting phenotypes tests function directly; DNA microarrays measure the expression of thousands of genes at once; and characterising the proteome present at a given developmental stage shows which gene products are active. All three are functional studies.
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