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Which of the following is not an ionisation method?

Collision-induced dissociation

Electron impact

Chemical ionisation

Electrospray

  • A.Chemical ionisation
  • B.Electrospray
  • C.Collision-induced dissociation
  • D.Electron impact

Answer: C

Collision-induced dissociation fragments ions that already exist rather than creating them, so it belongs to the tandem experiment rather than to the source. The other three are genuine ionisation methods. Distinguishing what makes ions from what breaks them is essential when a method is being designed, since the two steps address quite different problems.

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