Discussion
Which one of the following is NOT correct about antibiotic resistance mechanism in microbes?
Answer: A
The incorrect statement is that Mycoplasma is naturally resistant to penicillins due to presence of R plasmid.
Penicillins act by blocking the synthesis of peptidoglycan in the cell wall. Mycoplasma has no cell wall at all, so it is intrinsically resistant: the drug has no target. That is natural resistance, not resistance carried on an R plasmid.
The other statements are correct. The outer membrane of Gram-negative bacteria keeps out penicillin G, β-lactamases hydrolyse the β-lactam ring, and efflux pumps that expel the drug are a recognised resistance mechanism.
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