Discussion
Which of the following test(s) may establish retrospective diagnosis of streptococcal infection?
Answer: D
Correct answer: All of these
All three detect antibody rather than the organism, so all can establish an infection that has already resolved - which is exactly what is needed when rheumatic fever or glomerulonephritis appears weeks later. The ASO test detects antibody to streptolysin O, anti-DNase B is more reliable after skin infection, and the streptozyme test screens for several streptococcal antibodies at once.
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