Discussion
Metabolic intermediates provide the backbone for the synthesis of amino acids. Match the metabolic intermediates listed in Column I with their corresponding amino acids given in Column II.
| Column I | Column II |
|---|---|
| P. α-Ketoglutarate | i. Histidine |
| Q. Ribose 5-phosphate | ii. Glutamate |
| R. 3-Phosphoglycerate | iii. Aspartate |
| S. Phosphoenolpyruvate | iv. Phenylalanine |
| v. Serine |
Answer: A
The correct match is P-ii; Q-i; R-v; S-iv.
- α-Ketoglutarate is transaminated or reductively aminated to glutamate.
- Ribose 5-phosphate, as PRPP, supplies the carbon backbone of histidine.
- 3-Phosphoglycerate is oxidised and transaminated to serine.
- Phosphoenolpyruvate, with erythrose 4-phosphate, enters the shikimate pathway to phenylalanine.
Aspartate (iii) is made from oxaloacetate, which is not in Column I, so it is the spare. The last option sends 3-phosphoglycerate to phenylalanine and PEP to serine, the reverse of the two pathways.
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