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Which of the following is classified as a "Dissociative Anaesthetic"?

  • A.Ketamine
  • B.Diazepam
  • C.Thiopentone sodium
  • D.Nitrous oxide

Answer: A

The dissociative anaesthetic is ketamine.

Ketamine blocks NMDA glutamate receptors and produces dissociative anaesthesia: the patient seems detached from the surroundings, with profound analgesia and amnesia, while the eyes may stay open and reflexes and breathing are largely kept.

Diazepam is a benzodiazepine used for sedation and seizures. Thiopentone sodium is an ultra-short-acting barbiturate given intravenously to induce anaesthesia. Nitrous oxide is an inhaled anaesthetic gas, a good analgesic but a weak anaesthetic. None of them produces the dissociative state.

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