Discussion
A Fab fragment :
Answer: C
A Fab fragment binds antigen.
Papain cleaves an IgG molecule above the hinge into two Fab (fragment, antigen-binding) pieces and one Fc (crystallisable) piece. Each Fab contains a whole light chain plus the VH and CH1 domains of a heavy chain, so it keeps one antigen-binding site.
Pepsin cleaves below the hinge and gives a single F(ab')2 fragment, not Fab. Separating heavy and light chains by reducing the disulphide bonds gives free chains, not fragments, and Fab contains a complete light chain, so 'lacks light chains' is wrong.
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