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Weil-Felix reaction is based on sharing of antigens between

  • A.sheep RBCs and EB virus
  • B.mycoplasma and human O group RBCs
  • C.rickettsial antigens and antigens of certain strains of Proteus
  • D.none of these

Answer: C

Correct answer: rickettsial antigens and antigens of certain strains of Proteus

The Weil-Felix reaction works by heterophile agglutination: certain Proteus strains, OX-19, OX-2 and OX-K, happen to share carbohydrate antigens with the rickettsiae, so serum from a patient with typhus agglutinates them. The pattern of which strain is agglutinated points to the rickettsial group. It is convenient rather than accurate, and specific serology has largely replaced it.

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