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Agglutination reaction is more sensitive than precipitation for the detection of

  • A.antigens
  • B.antibodies
  • C.complement
  • D.antigen-antibody complexes

Answer: A

Correct answer: antibodies

Agglutination involves particulate antigen - whole cells or coated particles - so very little antibody is needed to produce a visible clumping, and the test detects antibody at concentrations well below what precipitation requires. This is why so many diagnostic serological tests are agglutination tests, and why soluble antigens are deliberately coated onto latex or red cells to convert precipitation into agglutination.

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