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Discussion

The test (s) based on the principle of toxin neutralization is/are

  • A.Nagler's reaction
  • B.Schick test
  • C.both (a) and (b)
  • D.none of these

Answer: C

Correct answer: both (a) and (b)

Both tests read the neutralisation of a toxin by antibody. In Nagler’s reaction, antitoxin on part of an egg yolk plate prevents the lecithinase of Clostridium perfringens from producing opalescence there. In the Schick test, diphtheria toxin injected intradermally produces a reaction only in those without enough circulating antitoxin to neutralise it.

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