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Antibodies recognize antigens

  • A.Via their hypervariable regions
  • B.By covalent bonding to specific epitopes
  • C.Have a similar high binding affinity regardless of their isotype
  • D.Can neutralise pathogens within host cells

Answer: A

Correct answer: Via their hypervariable regions

The antigen-binding site is formed by the three hypervariable loops, or complementarity determining regions, of the heavy chain paired with the three of the light chain. Binding is entirely non-covalent - hydrogen bonds, electrostatic and hydrophobic interactions and van der Waals forces - which is what makes it reversible and why affinity varies so widely between antibodies.

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