Discussion
The class of antibodies, which can cross placenta is
Answer: C
Correct answer: IgG
IgG is the only class transported across the placenta, carried actively by the neonatal Fc receptor on trophoblast. This gives the newborn several months of passive protection reflecting the mother’s immune experience. IgM is too large and lacks the receptor interaction, which is why IgM in cord blood indicates the infant’s own response and hence intrauterine infection.
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