Discussion
Type I hypersensitivity involves
Answer: C
Correct answer: IgE
Type I hypersensitivity is IgE-mediated. IgE binds through its Fc to high affinity receptors on mast cells and basophils, and when antigen cross-links two adjacent molecules the cell degranulates, releasing histamine and other mediators within minutes. This is the mechanism of hay fever, allergic asthma and anaphylaxis.
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