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One principal function of complement is to

  • A.inactivate perforins
  • B.mediate the release of histamine
  • C.Bind antibodies attached to cell surfaces and to lyse these cells
  • D.phagocytize antigens

Answer: C

Correct answer: Bind antibodies attached to cell surfaces and to lyse these cells

The classical pathway begins when C1q binds the Fc regions of antibody already attached to a cell surface, and the cascade that follows assembles the membrane attack complex, which perforates the membrane and lyses the cell. Complement also opsonises and generates chemotactic fragments, but lysis of antibody-coated cells is its defining function.

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