Discussion
Individuals unable to make the J protein found in certain immunoglobulins would be expected to have frequent infections of the
Answer: D
Correct answer: intestinal tract
The J chain is needed to assemble dimeric IgA and for its transport across the mucosal epithelium, so without it secretory IgA cannot be delivered to the gut lumen. The consequence is repeated intestinal infection, since the mucosal surface loses the antibody that normally prevents organisms from adhering to it.
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