Discussion
Class switching of immunoglobulins occurs
Answer: A
Correct answer: Usually with booster immunizations, going from IgM to IgG
Class switching happens as the response matures, particularly on re-exposure: the first encounter produces mainly IgM, and subsequent boosters produce predominantly IgG. The switch is driven by T-cell help and cytokines, and it recombines a different heavy chain constant region gene into place while leaving the specificity untouched.
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