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When a B-cell undergoes immunoglobulin class switching

  • A.the variable region of the light chain changes, but its constant region remains the same
  • B.the variable region of the light chain remains the same, but its constant region changes
  • C.the variable region of the heavy chain remains the same but its constant region changes
  • D.the variable region of the heavy chain changes but its constant region remains the same

Answer: C

Correct answer: the variable region of the heavy chain remains the same but its constant region changes

This is what makes class switching useful: recombination replaces the heavy chain constant region gene while leaving the assembled variable region intact, so the antibody keeps the specificity that was selected for and acquires new effector functions. The light chain is not involved at all.

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