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If you compare the B cell epitope against T cell epitope :

  • A.B cell epitopes are based more on primary sequence of protein antigen
  • B.B cell epitopes are based more on nature conformation of protein antigen
  • C.B cell epitopes are based more on presentation of antigen by MHC molecule
  • D.B cell epitopes are of continuous epitopes than the B cell epitope

Answer: B

B cell epitopes are based more on the native conformation of the protein antigen (printed 'nature conformation').

Antibodies and B-cell receptors bind intact antigen directly, recognising its three-dimensional surface. Most B cell epitopes are conformational (discontinuous), formed by residues brought together by folding, and they are lost when the protein is denatured.

T cell epitopes are the reverse: short linear peptides from the primary sequence, produced by processing and recognised only when presented by MHC molecules. So the options citing primary sequence and MHC presentation describe T cell epitopes, and the last option is garbled.

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