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Caspases exist in healthy cells as

  • A.genes that are transcribed only on demand
  • B.fragments that must be joined together
  • C.inactive precursors awaiting activation
  • D.fully active enzymes held in vesicles

Answer: C

Keeping them ready but inert lets the cell commit to death within minutes without waiting for new protein to be made. Activation is usually by cleavage, which is itself carried out by other caspases. Initiator caspases activate executioner caspases in a short cascade.

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