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The intrinsic pathway of apoptosis is triggered by

  • A.internal stress such as DNA damage
  • B.a death ligand binding a surface receptor
  • C.physical injury to the plasma membrane
  • D.loss of contact with the extracellular matrix only

Answer: A

Damage that cannot be repaired causes mitochondria to release cytochrome c, which assembles the apoptosome and activates the caspases. The extrinsic pathway begins outside the cell instead. Which route is taken depends on where the death signal originates.

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