Discussion
Assertion (A): The release of cytochrome c into the cytosol is a reliable signal of apoptosis.
Reason (R): Cytochrome c is normally confined to the space between the mitochondrial membranes.
Answer: C
Both are true and the reason explains the reliability: the protein has no business in the cytosol, so its presence there can only mean the mitochondrial outer membrane has been permeabilised. That permeabilisation is the point of no return in the intrinsic pathway.
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