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Discussion

Members of the Bcl-2 family regulate apoptosis by controlling

  • A.the permeability of the mitochondrial membrane
  • B.the rate at which the DNA is replicated in S phase
  • C.the assembly of the mitotic spindle at metaphase
  • D.the entry of glucose molecules into the cytoplasm

Answer: A

Some members promote release of cytochrome c and others prevent it, so the balance between them decides the cell's fate. The family is named after the gene first found overexpressed in a lymphoma. The balance is tipped rather than switched by any single member.

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