Discussion
Which of these bacteria is resistant to penicillin as it lacks a cell wall?
Answer: C
Correct answer: Mycoplasmas
Penicillin works by blocking the cross-linking of peptidoglycan, so it can only kill an organism that is building a cell wall. Mycoplasmas have no cell wall at all - only a sterol-strengthened membrane - so there is nothing for the drug to act on. Spirochaetes, cyanobacteria and bdellovibrios all have walls.
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