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The last step in synthesis of peptidoglycan is

  • A.attachment of a peptide to muramic acid
  • B.attaching two amino acids to form a cross-link
  • C.attachment of a portion of peptidoglycan to a membrane lipid
  • D.binding of penicillin to a membrane protein

Answer: B

Correct answer: attaching two amino acids to form a cross-link

The final step is transpeptidation: the peptide side chains of neighbouring glycan strands are joined, turning the layers into one continuous mesh that can resist turgor pressure. It happens outside the membrane, and it is the step penicillin blocks - which is why the drug kills only growing cells.

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