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Which component of the gram-negative cell wall is responsible for endotoxic activity ?

  • A.The O-antigen side chain
  • B.Lipid A of the lipopolysaccharide
  • C.Peptidoglycan
  • D.Lipoteichoic acid

Answer: B

Correct answer: Lipid A of the lipopolysaccharide

Lipid A anchors the lipopolysaccharide in the outer membrane and is the portion that triggers fever, hypotension and shock when released. The O-antigen determines serological type, and lipoteichoic acid belongs to gram-positive walls.

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