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The actual free energy change of a given biochemical reaction carried out under standard conditions with 1 M initial concentration of each of the reactants and products will be

  • A.equal to zero
  • B.equal to standard free energy change for the reaction
  • C.less than the standard free energy change for the reaction
  • D.greater than the standard free energy change for the reaction

Answer: B

The actual free energy change is equal to standard free energy change for the reaction.

The actual free energy change is related to the standard value by

\[ \Delta G = \Delta G^{\circ} + RT\ln Q \]

where Q is the ratio of product to reactant concentrations. With every reactant and product at 1 M, Q = 1 and \(\ln 1 = 0\), so \(\Delta G = \Delta G^{\circ}\) at the start of the reaction.

\(\Delta G\) is zero only at equilibrium, when Q equals the equilibrium constant, which these conditions do not describe. It would be less or greater than \(\Delta G^{\circ}\) only if Q were below or above 1.

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