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Which enzyme catalyze the conversion of Pyruvic Acid into Acetyl co-enzyme A in the respiratory process?

  • A.Pyruvic acid oxidase
  • B.Pyruvate synthetase
  • C.Aconitase
  • D.Pyruvate Dehydrogenase

Answer: D

The enzyme is pyruvate dehydrogenase.

After glycolysis, pyruvic acid enters the mitochondrion, where the pyruvate dehydrogenase complex carries out oxidative decarboxylation: one carbon is removed as CO2, NAD+ is reduced to NADH, and the remaining two-carbon acetyl group is joined to coenzyme A as acetyl CoA, which then enters the Krebs cycle.

Aconitase works inside the Krebs cycle, converting citrate to isocitrate. 'Pyruvic acid oxidase' and 'pyruvate synthetase' are not the enzymes that link glycolysis to the Krebs cycle in respiration.

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