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In an undamaged blood vessel, conversion of Prothrombin to Thrombin is prevented by

  • A.Fibrinogen
  • B.Calcium (Ca)
  • C.Factor VI
  • D.Heparin

Answer: D

The conversion is prevented by Heparin.

Heparin is a natural anticoagulant produced by mast cells and found on the lining of blood vessels. It acts with antithrombin to block thrombin and the factors that form it, so prothrombin is not converted into thrombin and blood does not clot inside an undamaged vessel.

The other options are part of clotting, not its prevention. Fibrinogen is the soluble protein that thrombin turns into fibrin threads, calcium ions are needed at several steps of the clotting cascade, and the clotting factors drive the cascade forward. (Factor VI is in fact no longer recognised as a separate factor.)

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