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Cross-contamination of cell lines, in which one line overgrows another, is a serious problem because

  • A.the contaminating cells will always die off quickly
  • B.it changes the colour of the medium unexpectedly
  • C.it can only be detected using electron microscopy
  • D.published results may describe the wrong cell type

Answer: D

Correct answer: published results may describe the wrong cell type

A faster-growing contaminant can replace a line entirely within a few passages, and the culture goes on looking healthy. Every experiment done afterwards then describes the contaminant while claiming to describe the original, and the literature accumulates conclusions attributed to the wrong tissue - sometimes for decades before anyone checks.

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