Discussion
Assertion (A): Journals increasingly require authors to authenticate their cell lines.
Reason (R): Many widely used lines have turned out to be cross-contaminated with others.
Answer: A
Correct answer: Both A and R are true, and R is the correct explanation of A
Both are true and the reason gives the cause of the requirement. Registers list hundreds of lines known to be misidentified, many of them widely used and many overgrown by HeLa. Short tandem repeat profiling settles a line’s identity cheaply, so journals and funders now require it - a response to a documented problem rather than a general tightening of standards.
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