Discussion
Assertion (A): The activity of a cyclin-dependent kinase varies through the cycle even though its own concentration does not.
Reason (R): The kinase is active only while bound to a cyclin, and cyclin levels oscillate.
Answer: A
Both are true and the reason gives the mechanism: the oscillation is imposed by the regulatory subunit rather than by the catalytic one, which is an economical way to produce a repeating cycle. Only the cyclin has to be made and destroyed each time round.
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