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Cyclins are removed at the appropriate moment by

  • A.storage in vesicles until needed again
  • B.targeted degradation in the proteasome
  • C.diffusion out through the nuclear pores
  • D.conversion into their partner kinases

Answer: B

Ubiquitin is attached to mark them for destruction, which makes the fall in concentration abrupt and irreversible. Irreversibility is what stops the cycle running backwards. Destroying the regulator rather than merely inhibiting it makes each step final.

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