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The spindle assembly checkpoint delays the cell until

  • A.the nuclear envelope has completely re-formed again
  • B.every last cyclin has been degraded by the proteasome
  • C.DNA replication has begun within both daughter cells
  • D.all chromosomes are correctly attached to the spindle

Answer: D

A single unattached kinetochore is enough to hold the cell at metaphase. The delay prevents chromosomes being distributed unequally, which would leave both daughters abnormal. Aneuploidy of this kind is a hallmark of many tumours.

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