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Growth factors influence the cell cycle chiefly by

  • A.degrading all of the tumour suppressor proteins
  • B.stimulating progression past the restriction point
  • C.supplying the nucleotides that replication needs
  • D.attaching themselves directly to the mitotic spindle

Answer: B

Binding a receptor at the surface starts a signalling cascade that raises cyclin D and pushes the cell through G1. A cell deprived of them arrests and may enter G0 instead. Dependence on external signals is one of the things cancer cells escape.

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