Discussion
Separase, activated at the metaphase to anaphase transition, acts by
Answer: A
Correct answer: cutting the cohesin holding sister chromatids
Separase is a protease, and its substrate is the cohesin ring encircling the sister chromatids. Cleaving it releases the sisters so the spindle can draw them apart, which is why anaphase begins abruptly and all together rather than chromosome by chromosome. Until that moment separase is held inactive by securin, whose destruction is the trigger.
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