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A cell exposed to ionising radiation during G1 will most likely

  • A.enter mitosis at once and divide the damage between daughters
  • B.lose its nuclear envelope permanently and irreversibly
  • C.arrest at the G1 checkpoint while repair is attempted
  • D.proceed immediately into S phase entirely unaffected

Answer: C

Damage is detected and p53 halts the cycle so that repair can be attempted. Whether the cell resumes or dies depends on how far the repair succeeds. Radiotherapy relies on tumour cells handling this damage worse than normal ones.

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