Discussion
Cyclin D is chiefly associated with progression through
Answer: B
Correct answer: G1 towards the restriction point
Cyclin D is the sensor of growth factor signalling: its level tracks the mitogenic environment, and with its kinase partners it phosphorylates the retinoblastoma protein, releasing E2F and committing the cell past the restriction point into S phase. Because it links external signals to that commitment, it is one of the most frequently deregulated components in cancer.
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