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Autocrine signalling occurs when a cell

  • A.releases a hormone into the bloodstream
  • B.transfers ions through a gap junction
  • C.responds to a signal it released itself
  • D.signals to a cell touching it directly

Answer: C

Correct answer: responds to a signal it released itself

Autocrine signalling is a cell talking to itself: it secretes a molecule for which it carries the receptor. It is used to reinforce a decision a cell has already made - which is why it is common in development, where a group of neighbouring cells all releasing and receiving the same signal commits the whole group to one fate, and why it is a frequent feature of cancer cells driving their own proliferation.

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